In general, biopsies are performed either with a needle (percutaneous biopsy), or during a surgical procedure (open biopsy). In a percutaneous biopsy, a needle is passed into the tissue to be biopsied, and cells are removed through the needle. Depending on the location of the tissue to be biopsied, needle biopsies are often performed under X-ray (usually CT scan) guidance. If more tissue is required than can be obtained in a needle biopsy, open biopsy is required. This is often the case for soft tissue masses that are suspected of being cancer. In these cases, an incision in the skin is made, and a small piece of the tissue to be biopsied is removed. If the tissue to be biopsied is in the abdomen, and cannot be safely accessed with a needle, the abdomen must be opened in the operating room and the tissue biopsied.
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